Wrong-way driving is a growing concern on roadways, especially because resulting crashes tend to be severe and often result in fatalities and serious injuries. Transportation agencies are deploying on-road countermeasures at select locations; however, these can only go so far to reduce wrong-way crashes. In-vehicle navigation systems and mobile applications hold significant potential to reduce wrong-way crashes. These interventions could reach many more drivers than on-road countermeasures alone, by providing alerts at all times and all locations while the application is being used. The ENTERPRISE Pooled Fund is conducting outreach to automobile manufacturers and mobile app developers to explore the potential for in-vehicle navigation systems and mobile apps to provide wrong-way driving alerts.